Mismatch binding, ADP–ATP exchange and intramolecular signaling during mismatch repair
نویسندگان
چکیده
منابع مشابه
Mismatch repair during homologous and homeologous recombination.
Homologous recombination (HR) and mismatch repair (MMR) are inextricably linked. HR pairs homologous chromosomes before meiosis I and is ultimately responsible for generating genetic diversity during sexual reproduction. HR is initiated in meiosis by numerous programmed DNA double-strand breaks (DSBs; several hundred in mammals). A characteristic feature of HR is the exchange of DNA strands, wh...
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Mismatch Repair in Bacteria and Eukaryotes Mismatch repair in the bacterium Escherichia coli is initiated when a homodimer of MutS binds as an asymmetric clamp to DNA containing a variety of base-base and insertion-deletion mismatches. The MutL homodimer then couples MutS recognition to the signal that distinguishes between the template and nascent DNA strands. In E. coli, the lack of adenine m...
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We read the recent publications of Ychou et al. [1, 2] on ‘adjuvant’ irinotecan-based chemotherapy in high-risk localized colorectal cancer (CRC) and after resection of liver-confined metastatic disease with great interest. In contrast to the improved outcome provided by oxaliplatin-based adjuvant treatment of early-stage disease, there is now a body of evidence showing that the addition of iri...
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Mismatch repair reverses replication errors and inhibits recombination between diverged sequences. This has been suggested to be important in speciation, especially in prokaryotes, but theoretical analysis indicates that genetic divergence in bacterial populations is not constrained by naturally occurring recombination levels.
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ژورنال
عنوان ژورنال: DNA Repair
سال: 2016
ISSN: 1568-7864
DOI: 10.1016/j.dnarep.2015.11.017